Figure 4.

Grade of neurotoxicity development in patients treated with CD19 CAR T cell therapies is related to CAR domain structure composition. CAR domain structure is separated based on hinge (H), transmembrane (TM) and costimulatory (Costim) domain composition on the left y axis, while neurotoxicity grade is separated into grade 0–2 or grade 3+ on the right y axis. Each circle represents the percentage of patients in a single clinical trial listed in Table 1 that developed the corresponding grade of neurotoxicity (grade 0–2 and grade 3+). Middle line represents the mean percentage of patients with the corresponding grade of neurotoxicity and error bars represent the SEM (Table S3).