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. 2020 Dec 25;13(1):38. doi: 10.3390/cancers13010038

Table 1.

Summary of FMC63 (CD19) CAR T cells in clinical trials with published clinical outcomes.

NCT ID Tumour Type No. of Patients CAR Name CAR Domain Structure Gene Transfer Method CAR-T Cell Dose Ref
ScFv Hinge TMD Costim Signal
NCT02842138 FL 7 CD19-BBz(86) FMC63 CD8α CD8α 41BB CD3ζ lentivirus 3 × 108–3.7 × 108 [15]
NCT02842138 DLBCL 13 CD19-BBz(86) FMC63 CD8α CD8α 41BB CD3ζ lentivirus 6 × 106–3.2 × 108 [15]
NCT02030834 DLBCL, FL 28 CTL-019 FMC63 CD8α CD8α 41BB CD3ζ lentivirus 3.1 × 106–8.9 × 106/kg [39]
NCT02445248 DLBCL 111 CTL-019 FMC63 CD8α CD8α 41BB CD3ζ lentivirus 1 × 107–6 × 108 [40]
NCT01626495
NCT01029366 		B-ALL, T-ALL 30 CTL-019 FMC63 CD8α CD8α 41BB CD3ζ lentivirus 1 × 107–1 × 108/kg [30,41]
NCT02435849 B-ALL 75 CTL-019 FMC63 CD8α CD8α 41BB CD3ζ lentivirus 3.1 × 106/kg [42]
NCT02631044 DLBCL 268 JCAR017 FMC63 CD8α CD8α 41BB CD3ζ lentivirus 5 × 107–1.5 × 108 [43]
NCT01860937 B-ALL 25 19-28z FMC63 CD28 CD28 CD28 CD3ζ gamma retrovirus 1 × 106–3 × 106/kg [44]
NCT01044069 B-ALL 53 19-28z FMC63 CD28 CD28 CD28 CD3ζ gamma retrovirus 1 × 106–3 × 106/kg [23,45]
NCT00466531 CLL 16 19-28z FMC63 CD28 CD28 CD28 CD3ζ gamma retrovirus 2.6 × 106–3.2 × 107 [46]
NCT01840566 DLBCL, FL, MZL, MCL 15 19-28z FMC63 CD28 CD28 CD28 CD3ζ gamma retrovirus 5 × 106–1 × 107/kg [47]
NCT02601313 MCL 68 KTE-X19 FMC63 CD28 CD28 CD28 CD3ζ gamma retrovirus 2 × 106/kg [48]
NCT02348216 DLBCL, PMBCL, TFL 101 KTE-C19 FMC63 CD28 CD28 CD28 CD3ζ gamma retrovirus 2 × 106/kg [49]
NCT00924326 DLBCL 17 CAR-19 FMC63 CD28 CD28 CD28 CD3ζ gamma retrovirus 1 × 106–2 × 106/kg [50]
NCT01593696 B-ALL 21 FMC63-28z FMC63 CD28 CD28 CD28 CD3ζ gamma retrovirus 3 × 104–3 × 106/kg [51]
NCT02963038 B-ALL 10 SENL-B19 FMC63 CD28 CD28 41BB CD3ζ lentivirus 3 × 105–1.6 × 106/kg [36]
NCT01865617 LBCL, FL, MCL 32 - FMC63 IgG4 CD28 41BB CD3ζ lentivirus 2 × 105–2 × 107/kg [37,38]

B-ALL, B cell acute lymphoblastic leukemia; CLL, chronic lymphocytic leukemia; DLBCL, diffuse large B cell lymphoma; FL, follicular lymphoma; MCL, mantle cell lymphoma; MZL, marginal zone lymphoma; PMBCL, primary mediastinal large B cell lymphoma.