Figure 5.

Neural activity selects Myosin IIB and VI in distinct dynamin isoform-mediated SV resupply pathways. Schematic drawing of SV resupply to the release site by myosin VI and IIB through distinct SV membrane recycling pathways mediated by dynamin isoforms. *purple, SV reloading activated by slow Ca²⁺ rise; *orange, SV reloading activated by rapid Ca²⁺ rise. ?, Clathrin-coated vesicle endocytosis is under debated [3,13]. SV clusters are classified into two pools: release-readily vesicles on the active zone membrane [57] and replacement site vesicles [8]. Adapted from Lu et al., 2009 [60]; Tanifuji et al., 2013 [85]; Mori et al., 2014 [86]; Hayashida et al., 2015 [64].