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. 2020 Dec 28;22(1):219. doi: 10.3390/ijms22010219

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Model of regulation of the translation elongation factor eIF5A expression by nutrient availability through different signalling pathways. Under nutrient availability conditions, glucose signalling via TOR up-regulates eIF5A expression to facilitate cytoplasmic translation, and glycolysis predominates over mitochondrial respiration. Under low glucose and/or non-fermentative carbon sources, TOR positive eIF5A regulation is inhibited, but eIF5A expression is up-regulated by the increase in heme levels and subsequent Hap1 activation. In these conditions, eIF5A promotes, additionally to cytoplasmic translation, not-well known functions in mitochondrial respiration.