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. 2020 Dec 31;22(1):364. doi: 10.3390/ijms22010364

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transcriptome profiling of proximal colon in inflammatory bowel disease (IBD) and control mice: (A) unsupervised hierarchical clustering based on the 500 genes with the highest variances, showing a clear separation between control and IBD groups; (B) the network surrounding the top upstream regulator Il10ra as identified by IPA; and (C) diseases and functions predicted to be affected by differentially expressed genes, using Fisher’s exact test at a significance threshold of p = 0.05, via IPA.