Table 1.
ECM proteins with immune modulatory functions in colorectal (CRC), gastric (GC) and pancreatic cancer (PC).
| Matrisome Category | Name | Digestive Cancer | Immune Modulatory Function | Secreted By |
|---|---|---|---|---|
| Collagens | PC [31] GC [58] CRC [66] |
M2 macrophage polarization [66] T cell exclusion [58,59] T cell suppression [62] |
Stromal fibroblasts [31,185] Tumor cells [31,185] |
|
| Fibrous and non-fibrous glycoproteins | Fibronectin | PC [186] GC [187] CRC [188] |
Monocyte recruitment [74,78] Monocyte differentiation [76,77] |
Stromal fibroblasts [186] Monocytes/Macrophages [189] Tumor cells [189] |
| Laminin | PC [190] GC [191] CRC [192] |
T cell infiltration/exclusion [93] DC priming [96] |
Tumor basement membrane [82,83] | |
| Elastin | PC [193] CRC [102] |
Macrophage activation [102] | Stromal fibroblasts [100] | |
| Matricellular glycoproteins | SPARC/ Osteonectin |
PC [124] GC [194] CRC [195] |
Macrophage recruitment/location [125] M2 macrophage suppression [127] TGF-β suppression [129] T reg cell suppression [129] |
Stromal fibroblasts [124,195] Macrophages/macrophages [131] Tumor cells [196] |
| Osteopontin | PC [197] GC [198] CRC [199] |
CD8+ T cell suppression [141] Macrophage recruitment/differentiation [142] |
Tumor cells [200,201] Macrophages [201] |
|
| Periostin | PC [202] GC [156] CRC [155] |
Macrophage recruitment [155] M2 macrophage polarization [156] |
Stromal fibroblasts [150,151,152] Tumor cells [152] |
|
| βig-H3/ TGFβi |
PC [168,169] GC [203] CRC [165] |
T cell suppression [168,170] | Stromal fibroblasts [168,203] Tumor cells [168,203] Macrophages [173] |
|
| Proteoglycans | Versican | PC [204] GC [205] CRC [176,206] |
Macrophage differentiation [176] Macrophages- and DC-mediated T cell activation [178,179] T reg cell recruitment [181] |
Stromal fibroblasts [174,207] Tumor cells [174,207] Infiltrating leukocytes [174,207] |