Table 4.
Antiplasmodial activity of compounds 3 and 4.
| Compound | Chloroquine-Sensitive (D6)-Clone | Chloroquine-Resistant (W2)-Clone | Cytotoxicity to Vero Cells | ||
|---|---|---|---|---|---|
| IC50 µg/mL (µM) | SI | IC50 µg/mL (µM) | SI | IC50 µg/mL (µM) | |
| 3:1 mixture of 1 and 2 | NA | NA | NC | ||
| 3 | NA | NA | NC | ||
| Fraction containing 4 a | <0.523 (<1.17) | >9 | <0.523 (<1.17) | >9 | NC |
| Chloroquine b | 0.016 (0.03) | 496.6 | 0.16 (0.31) | 48.1 | NC |
| Artemisinin b | 0.0056 (0.02) | 845 | 0.003 (0.01) | 1690 | NC |
a this fraction showed 100% inhibition at the lowest concentration tested (0.523 µg/mL). b Positive controls, IC50 = concentration causing 50% growth inhibition, NA = not active at the highest concentration tested (4.76 µg/mL), NC = no cytotoxic at the highest concentration tested (4.76 µg/mL), S. I. (selectivity index) = IC50 for cytotoxicity/IC50 for antiplasmodial activity.