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Manganese doped melanin-like nanoparticles for dual-model MRI in vitro and vivo. (a) Synthesis procedure and theranostic applications of Mn2+-melanin-like NPs. (b) T1 WI and T2 WI at various magnetic fields (MFs). The linear relationship for the (c) r1 and (d) r2 relaxivities of MnEMNPs as a function of Mn2+ concentration at various MFs. (e) In vivo theranostic evaluation of U87MG tumor as a function of time after injection with MnEMNPs [79].
