Figure 11.

A transdermal MN-based vaccine patch for photothermal assisted immunotherapy. (a) Schematic illustration of melanin-based transdermal vaccination. (b,c) anti-tumor effect of local cancer immunotherapy treatment toward distant B16F10 tumors. Average tumor volumes in vaccinated mice rechallenged with either B16F10 cells or BP cells on day 80 (b) and Kaplan-Meier survival curves for rechallenged mice (c) [109]. Data points represent mean ± SD (n = 8). Error bars indicate SD. Statistical significance was calculated by Student’s t test and log-rank test (NS, p > 0.05; *** p < 0.001).