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. 2021 Jan 2;22(1):406. doi: 10.3390/ijms22010406

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The working model for the CK2 down-regulation-mediated expression of SASP factors. CK2 down-regulation induces SIRT1 inhibition and AKT up-regulation, which elevate the nuclear import of RelA/p65 by increasing RelA/p65 acetylation and IκB destabilization, respectively. Subsequently, active NF-κB stimulates the transcription of SASP genes, including MMP2, IL-6, and IL-1β. LPS down-regulates CK2. The antisense inhibitors of miR-186, miR-216b, miR-337-3p, and miR-760 exhibit anti-inflammatory effects.