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. 2020 Dec 31;22(1):347. doi: 10.3390/ijms22010347

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Interaction strength correlates with gene coding, regulatory features, and nFGFR1 in ESC TADs. 200 TADs of 480 kb stacked as rows in descending order by interaction strength within each TAD. Heatmaps show the feature span (gene coding and regulatory features) or strength (interaction strength, RNA FPKM, nFGFR1 binding) throughout each TAD and a mean plot of the heatmap rows in 5 TAD bins. Pearson’s R values were calculated between interaction strength and each of the corresponding attributes in 5 TAD bins. Right panels to each heatmap show average interaction strength sorted feature enrichments across same sized TADs. Z-Score statistics indicate bins which are outside the mean of all bins p < 0.05; p < 0.01; p < 0.005.

Inline graphic — Interaction strength correlates with gene coding, regulatory features, and nFGFR1 in ESC TADs. 200 TADs of 480 kb stacked as rows in descending order by interaction strength within each TAD. Heatmaps show the feature span (gene coding and regulatory features) or strength (interaction strength, RNA FPKM, nFGFR1 binding) throughout each TAD and a mean plot of the heatmap rows in 5 TAD bins. Pearson’s R values were calculated between interaction strength and each of the corresponding attributes in 5 TAD bins. Right panels to each heatmap show average interaction strength sorted feature enrichments across same sized TADs. Z-Score statistics indicate bins which are outside the mean of all bins p < 0.05; p < 0.01; p < 0.005.