Figure 9.

Fenofibric acid did not interfere with paclitaxel-induced cytotoxicity in ovarian tumor cells. SKOV-3 and CAOV3 cells in 12-well plates were treated with paclitaxel (PAC, 7.5 nM in SKOV-3 and 25 nM in CAOV-3), fenofibric acid (FA, 40 mM) or their combination (PAC+FA) for 2 days. The cells were trypsinized and cell numbers/well were quantified with a Coulter counter (a,c). The viabilities of treated cells including both adherent and non-adherent cells were determined with Trypan blue exclusion (b,d). The results are presented as mean + SD of triplicate assays. (*: p < 0.05, **: p < 0.01. Not significant (ns) compared to paclitaxel treated groups.)