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. 2020 Dec 29;22(1):271. doi: 10.3390/ijms22010271

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Neutrophil and macrophage infiltration in renal ischemia/reperfusion injury (IRI). Groups of mice (n = 10) were treated with vehicle, 10 or 30 mg/kg/BID GS-642462 and compared to sham controls (n = 6). (A–C) Immunostaining of Ly6G+ peroxidases. (A) Sham control lacks neutrophils. (B) Vehicle-treated IRI shows many infiltrating neutrophils in an area of tubular damage. (C) IRI treated with 30 mg/kg GS-642362 shows a dramatic reduction in neutrophil infiltration. Bar = 100 µm. (D) Graph of Ly6G+ neutrophils. RT-PCR analysis of mRNA levels for (E) CD68, (F) CCL2, (G) TNF, and (H) IL-2. N.S., not significant.