Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cyclophilin expression and tubular damage in the day 7 unilateral ureteric obstruction (UUO) model (n = 8 to 10/group). RT-PCR for mRNA levels of (A) CypA and (B) CypD. (C–E) Periodic-acid-Schiff-stained kidney sections. (C) Normal mouse kidney. (D) Vehicle-treated UUO showing marked tubular dilation. (E) UUO treated with 30 mg/kg GS-642362 also shows marked tubular dilation. Bar = 200 µm. (F) Graph of tubular damage. (G) RT-PCR for mRNA levels of the tubular damage marker, NGAL/LCN2.
