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Cell death in the day 7 unilateral ureteric obstruction (UUO) model (n = 8 to 10/group). (A–C) TUNEL staining. (A) Normal mouse kidney. (B) Vehicle-treated UUO showing small numbers of TUNEL+ tubular cells in the cortex. (C) UUO treated with 30 mg/kg GS-642362 shows a clear reduction in the number of TUNEL+ cells. Bar = 100 µm. (D) Graph of TUNEL+ cells. N.S., not significant.
