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. 2020 Dec 29;22(1):271. doi: 10.3390/ijms22010271

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Macrophage infiltration in the day 7 unilateral ureteric obstruction (UUO) model (n = 8 to 10/group). (A–D) Immunostaining for F4/80+ macrophages. (A) Normal mouse kidney showing resident F4/80+ macrophages. (B) Vehicle-treated UUO showing a significant increase in macrophages in the cortex. (C) UUO treated with 30 mg/kg GS-642362 shows a partial in macrophage infiltration. Bar = 100 µm. (D) Graph of the area of F4/80 macrophage staining. RT-PCR for mRNA levels of (E) CD68, (F) CCL2, and (G) IL-2. N.S., not significant.