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. 2020 Dec 29;22(1):271. doi: 10.3390/ijms22010271

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Renal fibrosis in the day 7 unilateral ureteric obstruction (UUO) model (n = 8 to 10/group). (A) Hydroxyproline assay of total collagen content. (B–D) Immunostaining for collagen IV. (B) Normal kidney shows fine staining of collagen IV in the glomerular and tubular basement membranes. (C) Vehicle-treated UUO shows a substantial increase in interstitial collagen IV staining. (D) UUO treated with 30 mg/kg GS-642362 shows a partial in interstitial collagen IV staining. Bar = 100 µm. (E) Graph of the area of interstitial collagen IV staining. (F) Graph of the area of interstitial staining for α-SMA. RT-PCR for mRNA levels of (G) collagen IV, (H) α-SMA/Acta2, (I) TGF-β1, and (J) PDGF-B. N.S., not significant.