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. 2020 Dec 31;22(1):380. doi: 10.3390/ijms22010380

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Ingenuity Pathway Analysis (IPA) of the 86 proteins in the dataset that were found to be significantly differentially expressed between the bulk/undifferentiated HC and OP samples. Some of the identified proteins (highlighted in pink) were shown to have cellular involvements in signaling network pathway interactions. In the core of the network (in red), interactions of MAPK, ERK 1/2, PI3K, and integrin connected to osteopathogenesis were identified. Proteins in grey and white colors represent molecules from the IPA database that make up the network. (B) Ingenuity Pathway Analysis (IPA) of 196 proteins with marked expression changes between undifferentiated, osteogenic, and chondrogenic differentiated MSSCs in both OP and HC cells. Some of these proteins (highlighted in pink, as described above) were implicated in different signaling networks involving bone and connective tissue disorders. The network analysis was generated through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com.

(A) Ingenuity Pathway Analysis (IPA) of the 86 proteins in the dataset that were found to be significantly differentially expressed between the bulk/undifferentiated HC and OP samples. Some of the identified proteins (highlighted in pink) were shown to have cellular involvements in signaling network pathway interactions. In the core of the network (in red), interactions of MAPK, ERK 1/2, PI3K, and integrin connected to osteopathogenesis were identified. Proteins in grey and white colors represent molecules from the IPA database that make up the network. (B) Ingenuity Pathway Analysis (IPA) of 196 proteins with marked expression changes between undifferentiated, osteogenic, and chondrogenic differentiated MSSCs in both OP and HC cells. Some of these proteins (highlighted in pink, as described above) were implicated in different signaling networks involving bone and connective tissue disorders. The network analysis was generated through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com.