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. 2020 Dec 28;22(1):204. doi: 10.3390/ijms22010204

Figure 2.

Figure 2

Curcumin is rapidly taken up by mitochondria in T-ALL cells. (a) Curcumin (50 µM) autofluorescence estimated by spectrofluorometry. (b) Dose-dependent uptake of curcumin by Jurkat cells. Data are mean ± SD (n = 12 from three independent experiments; **** p < 0.0001; one-way ANOVA). (c) Time course of curcumin (25 µM) uptake (green) by Jurkat cells. Red arrows indicate puncta of curcumin accumulation. (d) Co-localization of curcumin (25 µM, 10 min incubation) with the mitochondrial-selective fluorophore Mitotracker Red (MtRed). (e) Spatial distribution of curcumin and MtRed fluorescence intensity along the cell axis within a single Jurkat cell.