Table 1.

In silico ADME parameters for PADPZ.

Water Solubility
Log S (ESOL)	−4.50
Solubility	1.38 × 10−2 mg/mL; 3.20 × 10−2 mol/L
Class	Moderately soluble
Pharmacokinetics
GI absorption	High
BBB permeant	Yes
P-gp substrate	Yes
CYP1A2 inhibitor	No
CYP2C19 inhibitor	No
CYP2C9 inhibitor	No
CYP2D6 inhibitor	Yes
CYP3A4 inhibitor	Yes
Lipinski	Yes; 0 violation