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KIT variants reported in mastocytosis. Variants frequently observed in pediatric patients with CM are shown in red, whereas the KIT p.D816V mutation (pathogenic variant) recurrently found in adult SM patients is shown in green. Abbreviation: ECD: Extracellular domain; JMD: Juxtamembrane domain; KID: Kinase insert domain; PTD: phosphotransferase domain; KD1, tyrosine kinase domains; TMD: transmembrane domain.
