Table 3.

Summary of the published data on IL31 gene polymorphisms in mastocytosis [28].

Gene	Polymorhism	Effect on Gene/Protein Function	Effects on Risk of Mastocytosis and Prognosis
IL31	−1066G > A (rs 11608363)	Not known	Not increase mastocytosis risk
	−2057G > A (rs 6489188)	Not known	−2057AA genotype increase the risk of mastocytosis in adult patients with CM and SM
	IVS2 + 12A > G	Noncoding intronic variant	AA and AG genotypes increased the risk of mastocytosis in adults and children with CM