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Summary of the published data on IL6 and IL6R gene polymorphisms in mastocytosis.
| Gene | Polymorhism | Effect on Gene/Protein Function | Effects on Risk of Mastocytosis and Prognosis | References |
|---|---|---|---|---|
| IL6 | −174G > C (rs 1800795) |
−174G high transcription variant | No association with mastocytosis | [29] |
| IL6R | p.D358A (rs 9192284) |
Misense variant | homozygous AA carriers of the missense variant had lower risk for mastocytosis than those with the AC or CC genotypes | [29] |
