Table 5.
Summary of the published data on TLR genes polymorphisms in mastocytosis.
| Gene | Polymorphism | Effect on Gene/Protein Function | Effects on Risk of Mastocytosis and Prognosis | References |
|---|---|---|---|---|
| TLR2 | p.R753Q (rs5743708) | 753Q variant encode non-functional receptor | Presence of 753Q variant of TLR-2 gene increased the risk of systemic mastocytosis | [30] |
| TLR4 | 896A > G (rs496790) | intronic variant | Not increase mastocytosis risk | [30] |
| TLR9 | −1237C > T (rs5743836) | CC lower transcription rate | No association with mastocytosis | [30] |