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. 2021 Jan 1;26(1):181. doi: 10.3390/molecules26010181

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of ECN (10 mg/kg) on the COX-2, iNOS, TNFα, IL-1β and IL-6 expression in the spinal cord and sciatic nerve tissue using PCR. (A) ECN (10 mg/kg) significantly inhibited the COX-2 in the sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (B) ECN (10 mg/kg) significantly inhibited the COX-2 in the sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. (C) ECN (10 mg/kg) significantly inhibited the iNOS in the sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (D) ECN (10 mg/kg) significantly inhibited the iNOS in the sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. (E) ECN (10 mg/kg) significantly inhibited the TNF-α in the sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (F) ECN (10 mg/kg) significantly inhibited the TNF-α in sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. (G) ECN (10 mg/kg) significantly inhibited the IL-1β in the sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (H) ECN (10 mg/kg) significantly inhibited the IL-1β in the sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. (I) ECN (10 mg/kg) significantly inhibited the IL-6 in sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (J) ECN (10 mg/kg) significantly inhibited the IL-6 in sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. The data is presented as the mean (n = 3) ± S.D. Different letters meant statistically significant differences: (***) p < 0.001 indicate significant differences from the PSNL control group. (###) indicate significant differences from the normal control group. *** p < 0.001 (two-way ANOVA followed by Dunnett’s test).

Effect of ECN (10 mg/kg) on the COX-2, iNOS, TNFα, IL-1β and IL-6 expression in the spinal cord and sciatic nerve tissue using PCR. (A) ECN (10 mg/kg) significantly inhibited the COX-2 in the sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (B) ECN (10 mg/kg) significantly inhibited the COX-2 in the sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. (C) ECN (10 mg/kg) significantly inhibited the iNOS in the sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (D) ECN (10 mg/kg) significantly inhibited the iNOS in the sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. (E) ECN (10 mg/kg) significantly inhibited the TNF-α in the sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (F) ECN (10 mg/kg) significantly inhibited the TNF-α in sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. (G) ECN (10 mg/kg) significantly inhibited the IL-1β in the sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (H) ECN (10 mg/kg) significantly inhibited the IL-1β in the sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. (I) ECN (10 mg/kg) significantly inhibited the IL-6 in sciatic nerve and spinal cord tissue on day 7 post-PSNL surgery. (J) ECN (10 mg/kg) significantly inhibited the IL-6 in sciatic nerve and spinal cord tissue on day 14 post-PSNL surgery. The data is presented as the mean (n = 3) ± S.D. Different letters meant statistically significant differences: (***) p < 0.001 indicate significant differences from the PSNL control group. (###) indicate significant differences from the normal control group. *** p < 0.001 (two-way ANOVA followed by Dunnett’s test).