Skip to main content
. 2020 Dec 24;18(1):68. doi: 10.3390/ijerph18010068

Figure 3.

Figure 3

Urolithin A attenuated inducible nitric oxide synthase expression and promoted M2 microglial polarization. (A) BV-2 cells treated with LPS (500 ng/mL) for 3 h followed by ATP (2.5 mM) for 30 min with or without whole red raspberry polyphenols (10 µg/mL) or urolithin A (10 µM). Gene expression levels measured by RT-qPCR for iNos. (B) BV-2 cells treated with IL-4 (100 ng/mL) and IL-13 (10 ng/mL) for 24 h with or without whole red raspberry polyphenols (10 µg/mL) or urolithin A (10 µM). Gene expression levels measured by RT-qPCR for Ym1. All values are represented as the mean ± SEM. Treatments with different letters indicate significant differences by one-way ANOVA, p < 0.05. IL = interleukin; LPS = lipopolysaccharide; RRW = whole red raspberry polyphenols; UroA = urolithin A.