Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 31;22(1):363. doi: 10.3390/ijms22010363

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Compared to untreated controls, TNFα (20 ng/mL, 24 h) exposure induced mitochondrial fragmentation in human ASM (A) associated with reduced Mfn2 and increased Drp1 protein levels (B). The extent of mitochondrial fragmentation was assessed by calculating (C) form factor and (D) aspect ratio of mitochondria labeled using MitoTracker Red (A). In B, cells were dissociated from ASM samples from n = 5 patients and divided into TNFα treated and untreated control groups. In C and D, multiple mitochondria/cells were measured from ASM cells isolated from n = 5 patients divided into TNFα treated and untreated control groups. (* denotes a significant difference between TNFα treated and untreated control groups; p < 0.05; t-test). All data are presented as scatter plots with lines indicating mean values. These figures are modified from presentations of previously reported results [4].