Skip to main content
. 2020 Dec 24;22(1):117. doi: 10.3390/ijms22010117

Figure 2.

Figure 2

Schematic of the main regulatory pathways that respond to HS transcription factors. The binding of heat shock protein (HSP)70/90 and heat shock transcription factor (HSF)A1s represses the activity of HSFA1s under nonstress conditions, whereas heat stress elicits the dissociation of HSFA1 from HSP70 and HSP90, leading to HSFA1 activation. Abbreviations: HSP, heat shock protein; HSF, heat shock transcription factor; ANN, annexin; JUB1, jungbrunnen 1; MBF1c, multiprotein-bridging factor 1c; DREB2A/2C dehydration-responsive element binding protein 2A/2C; NF-Y, nuclear factor Y; DPB3-1, DNA polymerase II subunit B3-1; ROS, reactive oxygen species; BIP, binding immunoglobulin protein; bIZP, basic leucine zipper; S-bzip60, spliced bZIP60; UPR, unfolded protein response; IRT1, inositol-requiring enzyme 1; miRNA, microRNA; lncRNA, long non-coding RNA; siRNA, small interfering RNA.