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. 2020 Dec 31;22(1):354. doi: 10.3390/ijms22010354

Figure 2.

Figure 2

The regulatory functions of CDK8 module in biotic stress response. (A) MED12 and MED13 reactivate the expression of a silenced DNA methylated SDC gene regulated by MORC1. (B) CDK8, MED12 and MED13 subunits interact with ERF1/ORA59 to regulate the expression of PDF1.2. (C) CDK8 is involved in the induced expression of AACT1 to regulate the biosynthesis of HCAAs for biotic stress response. (D) CDK8 represses the (ECERIFERUM) CER1 and CER6 gene expression to downregulate cuticle biosynthesis through interacting with WIN1, which binds to the GCC/DRE-box [45]. (E) CDK8 subunit integrates SA signaling through activating the expression of ICS1 and EDS5. (F) CDK8, WRKY6, WRKY18, and NPR1 form a complex to regulate the expression of pathogenesis-related (PR) genes. Light gray indicates the CDK8 kinase module, yellow indicates the head module, green indicates the middle module, and dark gray indicates the tail module.