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Biosynthesis of the SPMs Resolvins, Protectins and Maresins. EPA; Eicosapentaenoic Acid; 18-HpEPE, 17-HpDHA, 14-HPDHA: precursors of the SPMs during biosynthesis; Cox-1/2: Cyclooxygenases. ASS triggers biosynthesis of 18-HpEPE, 17-HpDHA intermediates via modification of Cox-enzymes. Maresins are produced by macrophages via a preliminary lipoxygenation step. Further lipoxygenases are required for SPM biosynthesis as depicted in Figure 1 [25].
