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The path of human trophoblast differentiation. Trophoblast stem cells are derived from the trophectoderm. The cytotrophoblasts differentiate in two ways: invasive extravillous trophoblast (EVT) and syncytiotrophoblast (STB). EVT can be divided into two subtypes, one of which invades deeply into the uterine wall as groups of cells, termed interstitial EVT, and the other invades the maternal decidual arterioles as endovascular EVT.
