Table 1.
Natural and synthetic ligands of peroxisome proliferator-activated receptors (PPARs).
| Receptor | Natural Ligands | Synthetic Ligands |
|---|---|---|
| PPARα | arachidonic acid | fibrates |
| linoleic acid | industrial plasticizers | |
| leukotriene B4 | naveglitazar | |
| docosahexaenoic acid | netoglitazone | |
| eicosapentaenoic acid | muraglitazar | |
| prostaglandin I2 (PGI2) | ||
| PPARβ/δ | polyunsaturated fatty acids (PUFAs) | carbaprostacyclin (cPGI2) |
| eicosanoids | iloprost | |
| PPARγ | fatty acids | rosiglitazone |
| oxidized low-density lipoprotein | thiazolidinedione | |
| 15-deoxy-12,14 prostaglandin J2 (15dPGJ2), | ciglitazone | |
| prostaglandin D2 | troglitazone | |
| 13- hydroxyoctadecadienoic acid (HODE) | GW1929 |