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. 2020 Dec 28;13(1):58. doi: 10.3390/cancers13010058

Figure 2.

Figure 2

cAMP/PKA signaling mediates the phosphorylation of connexins (Cxs) to promote cancer cell migration and malignant transformation. In the resting state (left panel), the whole complex consists of Cx, ZO-1, Ezrin, and a PKA pool anchored by Cx-bound ezrin. When cAMP levels increase (right panel), PKA regulatory subunits bind to four cAMP molecules, resulting in activated PKA catalytic subunits, increased Cx phosphorylation, and gap junction-mediated intercellular coupling [26,53,54,55]. Abbreviations: RIIα, PKA regulatory subunits and PKA C, PKA catalytic subunits.