Table 1.
Abnormalities of Cx43 expression of patients with mood disorders.
| Subject | Region (Cell) | Effect | Reference |
|---|---|---|---|
| Suicide | dorsal lateral prefrontal cortex (astrocyte) |
decrease (mRNA) | [50] |
| Major depression | locus coeruleus | decrease (mRNA) | [49] |
| Major depression | orbitofrontal cortex | decrease (protein) | [52] |
| Major depression | prefrontal cortex | decrease (mRNA) | [72] |
| Major depression (suicide) |
Neocortex, mediodorsal thalamus, caudate nucleus, cerebellum | decrease (mRNA) | [51] |
We searched MEDLINE using the keywords “(((connexin43) OR (microdissection)) AND ((suicide) OR (depression)) AND (humans) AND ((brain) OR (glia)))” for papers published by 1 November 2020. Relevant articles were obtained in full and assessed for inclusion independently by reviewers. Disagreements among reviewers were resolved via discussion to reach a consensus.