Table 5.
Summary of the effects of first-line mood stabilisers and other anticonvulsants on the expression and function of Cx43.
| Agent | Model (Region) | Treatment (Dose, Duration) |
Effect (Hemichannel) |
Reference |
|---|---|---|---|---|
| Carbamazepine | rat cortical astrocyte | in vitro (40–400 µM for 24 h) |
no effect (protein) | [110] |
| rat cortical astrocyte | in vitro (100 µM for 7 days) |
no effect (protein) (no effect) |
[2] | |
| Lacosamide | rat cortical astrocyte | in vitro (30–100 µM for 7 days) |
no effect (protein) (inhibition) |
[2] |
| Zonisamide | rat cortical astrocyte | in vitro (30 µM for 7 days) |
decrease (protein) (inhibition) |
[2] |
| Valproate | Rat (frontal) | in vivo (300 mg/kg for 21 days) |
no effect (protein) | [76] |
| rat cortical astrocyte | in vitro (350–1400 µM for 24 h) |
no effect (protein) | [110] | |
| rat cortical astrocyte | in vitro (1000–3000 µM for 7 days) |
increase (protein) (activation) |
[3] | |
| Gabapentin | rat cortical astrocyte | in vitro (60–600 µM for 24 h) |
no effect (protein) | [110] |
| Phenytoin | rat cortical astrocyte | in vitro (40–400 µM for 24 h) |
no effect (protein) | [110] |
| Diazepam | rat cortical astrocyte | in vitro (25 µM for 48 h) |
no effect (protein) | [77] |
We searched MEDLINE using the keywords “(((connexin) OR (hemichannel) OR (gap junction)) AND ((anticonvulsant) OR (psychotropic drugs)))” for papers published by 1 November 2020. Relevant articles were obtained in full and assessed for inclusion independently by reviewers. Disagreements among reviewers were resolved via discussion to reach a consensus.