AEX |
Anion exchange |
AP |
Alkaline phosphatase |
aTc |
Anhydrotetracycline hydrochloride |
AUC |
Area und the curve |
BCIP |
5-Bromo-4-chloro-3-indoxyl phosphate |
BSA |
Bovine serum albumin |
CEX |
Cation exchange |
CL |
Clearance |
Cmax
|
Maximum (or peak) serum concentration |
CNP |
C-type natriuretic peptide |
CORYNEX |
Corynebacterium glutamicum protein expression system |
COVID-19 |
Severe acute respiratory syndrome coronavirus 2 |
CTLA-4 |
Cytotoxic T-lymphocyte-associated protein 4 |
CV |
Column volume |
DCs |
Dendritic cells |
DPP-IV |
Dipeptidyl peptidase-4 |
ELISA |
Enzyme-linked immunosorbent assay |
ESETEC |
E. coli secretion technology |
ESI-MS |
Electrospray ionization mass spectrometry |
FPLC |
Fast protein liquid chromatography |
GCC |
Glucagon |
GIP |
Glucose-dependent insulinotropic polypeptide |
GLP-1 |
Glucagon-like peptide 1 |
GM-CSF |
Granulocyte-macrophage colony-stimulating factor |
GSH |
γ-L-Glutamyl-L-cysteinyl-glycine |
HBV |
Hepatitis B virus |
HCV |
Hepatitis C virus |
hGH |
Human growth hormone |
hIFN-α |
Human interferon 1 |
HIV-1 |
Human immunodeficiency virus I |
iRGD |
Internalizing arginylglycylaspartic acid peptide |
K3-EDTA |
Tri-potassium ethylenediaminetetraacetic acid |
MHC |
Major histocompatibility complex |
MOPS |
3-(N-morpholino)propanesulfonic acid |
NBT |
Nitro blue tetrazolium |
OD |
Optical density at 550 nm |
PAS |
Proline/alanine-rich sequence |
PAS-Tα1 |
N-terminally PASylated Tα1 |
PBS |
Phosphate-buffered saline |
PD |
Pharmacodynamics |
PEG |
Polyethylene glycol |
p.i. |
Post injection |
PK |
Pharmacokinetics |
ProTα |
Prothymosin alpha |
PTH |
Parathyroid hormone |
Q-TOF |
Quadrupole time of flight |
RBS |
Ribosome-binding site |
RGD |
Arginylglycylaspartic acid |
RimJ |
Ribosomal-protein-S5-alanine N-acetyltransferase |
RPC |
Reverse phase chromatography |
RT |
Room temperature |
SEC |
Size exclusion chromatography |
SDS-PAGE |
Sodium dodecyl sulfate polyacrylamide gel electrophoresis |
τ1/2α |
Half-life of distribution |
τ1/2β
|
Elimination half-life |
Tα1 |
Thymosin alpha 1 |
Tα1-PAS |
C-terminally PASylated Thymosin alpha 1 |
tetp/o
|
Tetracycline promoter/operator |
Th |
T helper cell |
tlpp
|
Lipoprotein terminator |
TLR-2 |
Toll-like receptor 1 |
TLR-9 |
Toll-like receptor 2 |
TMAE |
Trimethylaminoethyl |
tmax
|
Time to reach Cmax
|