Figure 2.

Current treatment options for BRAF^V600E mutant metastatic colorectal cancer (mCRC). According to most recent studies, treatment opportunities for BRAF^V600E mutant mCRC are fast developing if compared to only a decade ago. The panorama of treatment now includes the following options: surgery, combinations of cytotoxic drugs, targeted and immunological agents. All these approaches should be carefully evaluated when discussing the treatment approach to BRAF^V600E mCRCs in multidisciplinary teams (MDT). Given the peculiarity of this subset of mCRCs, clinical trial enrolment should always be considered also in the upfront setting. Based on current evidence, MSI BRAF^V600E mutant mCRC progressing to first line treatment with pembrolizumab should be managed as microsatellite stable (MSS) BRAF^V600E mutant mCRC. Keys: * = Metastasectomy should be -considered in liver limited disease in case of response or prolonged disease control obtained with medical treatments even if relapse-free and overall survival is poorer than BRAF wild-type mCRCs. Legend: mCRC = metastatic colorectal cancer. SD = stable disease; PD = progressive disease; PR = partial response. “Dashed line” means consider. “Continuous line” means recommended.