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Multiple types of chemical inducers for NRF2. (A) Classification of cysteine thiol-directed NRF2-inducers. (B) Electrophilic NRF2-inducers: DMF, sulforaphane and CDDO. (C) NRF2-inducers that inhibit the protein–protein interaction of KEAP1 and NRF2: compound 16 (Cpd16) and the derivative, PRL-295.
