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Tumor microenvironment (TME) composition. TME surrounding cancer cells consists of extracellular matrix (ECM) in which are embedded several stromal cells such as cancer associated fibroblasts (CAFs), tumor endothelial cells (TECs), cancer associated adipocytes (CAAs), and infiltrating immune cells (ICs), including tumorassociated macrophages (TAMs) and tumor infiltrating lymphocytes (TILs).
