Table 1.

MiRs involved in tumor–stroma metabolic crosstalk

miR	Position	TME Component	Cancer	Targets /Pathways	Metabolic Pathway	Ref
miR-424	Xq26.3	CAFs	melanoma	IDH3a	oxidative phosporylation	[73]
miR-122	18q21.31	CAFs	breast	PKM2	glycolysis	[74]
miR-105	Xq28	CAFs	breast	MYC	glutaminolysis/oxidative ohosphorylation	[75]
miR-155	21q21.3	CAFs	melanoma	n/a	oxidative phosporylation	[76]
miR-210	11p15.5	CAFs	melanoma	n/a	glycolysis	[76]
miR-210	11p15.5	CAFs	prostate	n/a	energy rich compounds	[77]
miR-21	17q23.2	CAFs	pancreatic	n/a	glycolysis	[78]
miR-144	17q11.2	CAAs	breast	MAP3K/ERK1/2/PPARg	glycolysis	[79]
miR-126	9q34.3	CAAs	breast	AMPK	glycolysis	[79]
miR-378	5q32	CAAs	gastrointestinal cancer	n/a	lipoylisis	[80]
miR-30c	6q13	TAMs	gastric cancer	REDD1	glycolysis	[81]
miR-365	16p13.12	TAMs	pancreatic	CDA	pyrimidine metabolism (in cancer cells)	[82]
miR-7a	9q21.32	TAMs	melanoma	insulin-Akt-mTOR	oxidative phosporylation	[83]
miR-145	5q32	TAMs	colorectal cancer	HDAC11	histon acetylation	[84]
let-7	9q22.32	TILs	mastocytoma	MYC EOMES	glycolysis	[85]
miR-155	21q21.3	TILs	melanoma	INPP5D	glycolysis	[86]
miR-143	5q32	TILs	esophagus	GLUT1	glycolysis	[87]
miR-101	1p31.3 9p21.1	TILs	ovarian	EZH2	epigenetic modifications	[88]
miR-26a	3p22.2	TILs	ovarian	EZH2	epigenetic modifications	[88]