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. 2020 Dec 24;22(1):99. doi: 10.3390/ijms22010099

Figure 1.

Figure 1

Social isolation immediately after stroke increases infarct size and mortality in aged female mice. (A) The experimental timeline illustrates the study design. Animals were screened for baseline behavior and immediately assigned to either pair-housing or isolation. The animals were randomly assigned and housed either in continued pair-housing or separated and housed singly (SI). Behavioral testing was performed on days 3, 7 and 14. Mice were euthanized on day 15 for infarct analysis. (B) Post-stroke SI (ST-SI) mice had significantly more atrophy compared to post-stroke pair-housed mice (ST-PH) (n = 9/group; * p = 0.024). Student’s t-test was used after the normality of data was confirmed. (C) The socially isolated mice had significantly higher mortality compared to pair-housed mice (n = 22 in SI; 16 PH initially. * p = 0.043). P value was obtained from the log-rank test.