Figure 4.

MetaCore protein network built by processing significant protein differences occurring among fibroblasts from dominant OI patients with lethal or non-lethal outcome. Experimental proteins, circled in blue, were cross-linked by using the shortest path algorithm. Only four of them did not enter the net (i.e., Microtubule-associated protein 1A; glycogen phosphorylase, brain form; chondroitin sulfate proteoglycan 4; nestin), thus suggesting a tight functional correlation among identified differences. Functions of network objects are visualized by different symbols, as reported in the legend. Edge colors and arrowheads indicate type and direction of protein interconnection, respectively.