Table 2.
Tandem Mass Tag-Mass Spectrometry (TMT MS) identified differentially expressed proteins occurring between primary fibroblast cell lines from type II and type III osteogenesis imperfecta (OI). The table also listed ratio values of the Lethal patients vs. Controls (CRTL) and Survived patients vs. CTRL comparisons relatively to the identified proteins of interest in Lethal vs. Survived.
| Swiss-Prot Accession Number |
Swiss-Prot Identifier |
Protein Description | Dead p. vs. CTRL | Dead p. vs. Survived p. ¥ | Survived p. vs. CTRL |
|---|---|---|---|---|---|
| P08473 | NEP_HUMAN | Neprilysin | 0.55 | 0.50 | NS |
| P26447 | S10A4_HUMAN | Protein S100-A4 | 0.26 | 0.63 | 0.42 |
| P21589 | 5NTD_HUMAN | 5’-nucleotidase | 0.40 | 0.64 | 0.69 |
| P07585 | PGS2_HUMAN | Decorin | 0.27 | 0.64 | 0.43 |
| P68431 | H31_HUMAN | Histone H3.1 | 0.57 | 0.66 | NS |
| P18085 | ARF4_HUMAN | ADP-ribosylation factor 4 | NS | 0.66 | NS |
| Q8WX93 | PALLD_HUMAN | Palladin | 2.06 | 1.51 | 1.35 |
| P35555 | FBN1_HUMAN | Fibrillin-1 | NS | 1.58 | NS |
| O15400 | STX7_HUMAN | Syntaxin-7 | 1.52 | 1.62 | NS |
| P05091 | ALDH2_HUMAN | Aldehyde dehydrogenase, mitochondrial | NS | 1.63 | NS |
| P78559 | MAP1A_HUMAN | Microtubule-associated protein 1A | NS | 1.68 | NS |
| Q13308 | PTK7_HUMAN | Inactive tyrosine-protein kinase 7 | 1.5 | 1.68 | NS |
| P09486 | SPRC_HUMAN | SPARC | 2.91 | 1.69 | 1.66 |
| P11216 | PYGB_HUMAN | Glycogen phosphorylase, brain form | NS | 1.70 | 0.6 |
| Q6UVK1 | CSPG4_HUMAN | Chondroitin sulfate proteoglycan 4 | 1.98 | 1.80 | NS |
| Q16527 | CSRP2_HUMAN | Cysteine and glycine-rich protein 2 | 2.44 | 1.88 | NS |
| P48681 | NEST_HUMAN | Nestin | 2.11 | 2.33 | NS |
¥ All the obtained ratios are supported by high statistics with p ≤ 0.001. In the Lethal vs. CRTL and Survived vs. CTRL columns, non-significant ratio values (0.5 ≤ ratio ≤ 1.5 and/or p ≥ 0.001) are indicated by NS.