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. 2020 Dec 27;22(1):186. doi: 10.3390/ijms22010186

Figure 8.

Figure 8

Natural and pharmacological activators of AMPK that bind in the ADaM site. TOP: palmitoyl-CoA (and other long chain saturated and monounsaturated acyl-CoA esters) are believed to the natural ligands that bind at the ADaM site, but they only activate β1-containing complexes. MIDDLE: synthetic activators that are selective for β1-containing complexes. BOTTOM: synthetic pan-β activators that activate both β1- and β2-containing complexes.