Table 2.
Multivariable stepwise Cox regression analysis of disease outcome: biomarker SNP panel and clinicopathologic characteristics in the discovery cohort of MMAIT stage IV BCG-treated patients.
| Variable | Disease-Free Survival | Overall Survival | ||
|---|---|---|---|---|
| Multivariable Analysis | Multivariable Analysis | |||
| * p-Value | HR (95% CI) |
* p-Value | HR (95% CI) |
|
| Immune-gene Panel SNP Score (Responder vs. Non-Responder) | 0.021 | 1.84 (1.09–3.13) | ||
| Age | ||||
| Gender | ||||
| Male/Female | ||||
| Lymph Node Positive | ||||
| 1 | ||||
| 0 | ||||
| 2–3 | ||||
| ≥4 | ||||
| Unknown | ||||
| Primary Site | ||||
| Extremity | ||||
| Head/Neck | ||||
| Mucosal | ||||
| Trunk | ||||
| Unknown | ||||
| M-Stage | ||||
| M1a | ||||
| M1b | ||||
| M1c | ||||
| Baseline LDH | ||||
| Normal /Elevated |
||||
| Number of Metastasis | ||||
| 1 | ||||
| 2–3 | ||||
| 4–5 | ||||
| ECOG Performance Status | ||||
| 0 | ||||
| 1 | ||||
| Unknown | ||||
| Prior Diagnosis of Stage III Melanoma | ||||
| Yes/No | ||||
| Previous Treatment for Melanoma | ||||
| Yes/No | ||||
* Variables that do not have a p-value shown were not significant. Bold font indicates p value ≤ 0.05.