Table 3.
Multivariable stepwise Cox regression analysis of survival: biomarker SNP panel and clinicopathologic characteristics in the validation cohort of MMAIT stage III BCG-treated patients.
| Variable | Disease-Free Survival | Overall Survival | ||
|---|---|---|---|---|
| Multivariate Analysis | Multivariate Analysis | |||
| * p-Value | HR (95% CI) |
* p-Value | HR (95% CI) |
|
| Immune-gene Panel SNP Score (Responder vs. Non-Responder) | 0.158 | 1.31 (0.90–1.93) | 0.025 | 1.67 (1.07–2.67) |
| Age | 0.007 | 1.02 (1.01–1.03) | ||
| Gender | 0.040 | 1.64 (1.02–2.71) | ||
| Male/Female | ||||
| Breslow | ||||
| ≤1.00 mm | 1.00 (Reference) | |||
| 1.01–2.00 mm | 0.71 (0.40–1.30) | |||
| 2.01–4.00 mm | 0.59 (0.32–1.11) | |||
| >4.00 mm | 0.98 (0.52–1.85) | |||
| Unknown | 0.55 (0.29–1.04) | |||
| Lymph Node Positive | 0.048 | |||
| 1 | 1.00 (Reference) | |||
| 2–3 | 0.014 | 1.81 (1.13–2.89) | ||
| ≥4 | 1.31 (0.67–2.44) | |||
| Primary Site | ||||
| Extremity | ||||
| Head/Neck | ||||
| Mucosal | ||||
| Trunk | ||||
| Unknown | ||||
| Palpable Lymph Node | ||||
| Yes/No | 1.33 (0.90–1.97) | 0.029 | 1.68 (1.05–2.69) | |
| Ulceration | 0.016 | |||
| No | 1.00 (Reference) | 1.00 (Reference) | ||
| Yes | 0.061 | 1.60 (0.98–2.63) | 0.008 | 2.08 (1.21–3.65) |
| Unknown | 1.02 (0.64–1.65) | 1.13 (0.65–2.00) | ||
* Variables that do not have a p-value shown were not significant. Bold font indicates p value ≤ 0.05.