Figure 4.

Immunohistochemical evaluation of cleaved caspase-3 (cytoplasmic), Bax, Bcl-2, Ki67, VEGFA, VEGFR-2, and MDA expression in rat mammary carcinoma cells after the administration of sumac in two doses. Data are expressed as mean ± SEM. Significant difference, * p < 0.05, ** p < 0.01, *** p < 0.001 vs. CONT, ⁺ p < 0.05 vs. SUM 0.1. Figure represents the expression of proteins quantified as the average percentage of antigen positive area in standard fields (0.5655 mm²) of tumor hotspot areas. The values of protein expression were compared between treated (SUM 0.1, SUM 1) and non-treated (control) carcinoma cells of female rats; >60 images for one marker were assessed.