Figure 1.

The time course of exercise-induced adaptations. Transient changes in metabolite sensing and signaling during/after exercise drive to gene transcription of early genes, myogenic regulators, genes of carbohydrate metabolism, lipid mobilization, transport and oxidation, mitochondrial metabolism and oxidative phosphorylation, and transcriptional regulators of gene expression and mitochondrial biogenesis [13]. DNA methylation is a regulatory point for transcription and may have a certain influence, although the current evidence suggest that exercise adaptations are regulated to a greater extent at the post-transcriptional level [14]. The time course changes following exercise have been described previously [15,16].