Figure 2.

Superposition of the prospective bound conformation of raloxifene onto the B2 receptor (orange) and the matching structure of raloxifene (yellow) from the virtual screening process. The 3D structure of the B2 receptor was constructed by homology modeling and reported previously [27]. Color spheres represent the pharmacophore points characteristic of the ligands binding to B2 receptor: dark blue represents a positive charge moiety; magenta a hydrogen bond accepting center; light blue a hydrogen bond donor/acceptor center; green an aromatic/lipophilic center.