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. 2020 Dec 23;26(1):31. doi: 10.3390/molecules26010031

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Potential mechanism of inositol on blocking the key biologic events in inflammatory process in inflammatory bowel disease (IBD), including IBD-caused free radicals, myo-inositol (1,4,5)-trisphosphate (IP3)-mediated AKT (protein kinase B) signaling, phospholipase A2/inositol-arachidonic acid metabolic pathway, and active eicosanoids, and blocking these key biologic events is crucial in inhibiting DNA damage/genetic instability, cell proliferation, and angiogenesis, and IBD-induced carcinogenesis.